"Independence" in the Qajar era, due to the encounter with the two phenomena of "colonialism" and "modernity", becomes one of the fundamental biopolitical issues and intellectual challenges of Iranian society. Therefore, Shiite scholars, in order to defend the independence of Iran, propose a specific system of thought that is rooted in the rules of Islam and influenced by the three principles of "Dar al-Islam and Dar al-Kufr", "the principle of negating the mustache", and the principle of "preserving the testicle of Islam". The issue of the present article is "independence" from the perspective of the approach of religious modernism in the Qajar era, emphasizing the opinions and actions of the Khorasani cleric. The study of the historical events that caused the issue of independence to become problematic in his thought, as well as how he understood this concept and his system of thought and instructions for achieving independence, considering the requirements of the turbulent pre- and post-constitutional era, is the question of the present research. The research, using a historical explanation method, proposes the hypothesis that Akhund Khorasani, regarding the religious foundations of independence, viewed the principle of "preserving the testicles of Islam" with a more comprehensive view than other jurists and paid detailed attention to the political, economic, and cultural dimensions of independence in his thought process. He had political and social action with three approaches of inspiration, support, guidance, and direct and pragmatic intervention towards the development of the issue of independence in his era.